Barcelona and Atletico Madrid will have to cut down the costs of their squads by more than 35 million euros ($A54 million) following new salary limits imposed by La Liga.
The new limits announced on Tuesday have been tightened to cope with the financial impact of the COVID-19 pandemic.
The figures, published twice annually after each transfer window, dictate how much teams can spend on players, coaches, support staff and their youth teams.
They are calculated in line with revenues, which have been obliterated by coronavirus restrictions preventing fans from attending matches for 12 months.
Barcelona are the club most acutely affected by the new limits and will be forced to reduce their costs by an additional 35.7 million euros to 347 million.
League leaders Atletico Madrid, meanwhile, must make savings of 35.4 million euros to meet a new budget of 217.3 million.
Champions Real Madrid have the largest salary limit of all 20 league sides with 473.3 million euros to spend, and are one of only four clubs allowed to increase their costs ahead of the next campaign.
La Liga president Javier Tebas praised clubs for adapting to the challenges of the pandemic, including not having fans in stadiums for almost a year and a reduced transfer market, which he said had cost clubs an estimated 2 billion euros.
“COVID-19 put Spanish football to the test but the end is in sight and we can make some positive conclusions,” he said.
“Despite earning 2 billion euros less, clubs, especially the big ones, have managed to cope with the crisis by reducing costs. This shows Spanish football is solvent.”
He predicted Spanish clubs would see revenues return to pre-pandemic levels in two years and hoped fans could return to stadiums before the end of the season, but said it was unlikely until late April at the earliest.