Mildura will enter a seven-day lockdown from midnight on Friday after COVID cases “increased in recent days”.
The Department of Health said that nine cases had been reported in the border community in recent days.
A further three cases were detected on Friday and will be formally reported on Saturday.
“The public health teams are concerned about onward transmission in the Mildura and have determined that the seven-day lockdown is needed to limit growth in cases,” the Department of Health said.
Under the lockdown, residents can only leave home for limited reasons.
They are to shop for necessary goods and services, caregiving or compassionate reasons, authorised work or permitted education, exercise and outdoor social interaction in limited groups, and getting a COVID-19 vaccine locally.
No visitors are allowed in the home, aside from intimate partners or the singles bubble arrangement.
Shopping, exercise and outdoor social interaction will be limited to 15km from residents’ homes.
Masks will be mandatory indoors and outdoors.
“Locals are asked to be on high alert for symptoms and get tested if any develop.
“A rapid response testing team has been deployed to provide support to the region.”
Two other regions will meanwhile exit lockdown as scheduled.
Shepparton and Moorabool will both conclude their heavy restrictions, bringing them in line with the remainder of regional Victoria.
It follows Victoria reporting its highest daily caseload increase since the beginning of the pandemic on Friday.